1
How is your house? Is it very big?
What is your house like? Is it very big?
How is she? Is she funny?
What is she like? Is she funny?
Use What is … like? to ask for a description of a person, place or thing: ‘What is your new teacher like?’ ‘What is the hotel like?’
Use How is …? to ask about someone’s health or the condition of something: ‘How is your mother?’ ‘How is your new car?’
2
How you know, I’ve been very busy recently.
As you know, I’ve been very busy recently.
Use as you know to introduce information that the other person already knows: ‘As you know, the office will be closed tomorrow.’
How do you know? is a question asking where someone got some information: ‘How do you know my name?’